Research at a Glance
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Research at Glance

My research spans basic redox biology, experimental models, translational hepatology and long-term clinical studies. The central goal is to understand mechanisms of liver injury and translate them into improved diagnosis, risk assessment and new disease concepts.

Key contributions include ultrasensitive detection of hydrogen peroxide, the GOX/CAT system for controlled modelling of peroxide and hypoxia, redox regulation of iron metabolism, inflammation-adapted interpretation of liver stiffness, and the sinusoidal pressure hypothesis of liver cirrhosis.

More recent work links alcohol-related liver disease to disturbed red blood cell turnover, hemolysis, erythrophagocytosis, hepatic iron overload and the emerging RBC–liver axis. These mechanistic studies are complemented by prospective cohorts, genetic collaborations, biomarker studies and selected clinical observations.

Selected publications

• The GOX/CAT system: A novel enzymatic method to independently control hydrogen peroxide and hypoxia in cell culture. Mueller S, Millonig G, Waite GN. Adv Med Sci. 2009;54:121–135.
• Inflammation-adapted liver stiffness values for improved fibrosis staging in patients with HCV and ALD. Mueller S et al. Liver Int. 2015;35(12):2514–2521.
• Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis. Mueller S. World J Gastroenterol. 2016;22(48):10482–10501.
• Evidence for alcohol-mediated hemolysis and erythrophagocytosis. Zheng C et al. Redox Biol. 2025;85:103742.