Sebastian Mueller, MD, PhD

Professor of Medicine,

CAR, University of Heidelberg 

VISCERA AG Bauchmedizin Bern 

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für Patienten/for patients
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Center for Alcohol Research (CAR)
Team (CAR)
Former Affiliations
Publications
Conferences
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Links                       

Former Homepage 2007-2026

Prof. Sebastian Mueller, M.D., Ph.D.

Research affiliations                              GOOGLE SCHOLAR        DFG GEPRIS

• Center for Alcohol Research, University of Heidelberg 

        Otto Meyerhof Zentrum, INF350, 69120 Heidelberg

        Direct contact:  

Visiting Professor positions at

• The Roger Williams Institute of Hepatology  in London/UK (affiliated to Kings's College London) and

• Guangxi Medical University in Nanning/VR China

• Past ESBRA president 

Clinical Affiliations

• Gastroenterology & Hepatology,

  Hôpital du Jura
  Fbg. des Capucins 30
  CH-2800 Delémont, Switzerland
  Tel (secretariat): +41 32 421 20 54
  Email (secretariat): gastrod@h-ju.ch
  Web: www.h-ju.ch

NEWS 

• New bool on "Alcohol and alcohol-related diseases" edited by Sebastian Mueller and Markus Heilig and published by Springer Nature. Addresses all aspects of alcohol-related diseases from addiction to alcohol-related liver disease, alcoholic hepatitis and cancer. With contributions from more than 100 authors from 17 countries. 2 volumes. 1600 pages 

   

• Webinar on "Alcoholic hepatitis" for the International Grand Rounds Series 2 of the British Society of Gastroenterology (Broadcasted on June 27th 2024)

   

   

  Recent publications: 

• 2026 Phosphatidylserine-Dependent Clearance of Damaged Red Blood Cells by Liver Sinusoidal Endothelial Cells in Alcohol-Related Liver Disease

Homepage!  

• 2025 Redoxbiology:  Evidence for alcohol-mediated hemolysis and erythrophagocytosis

We identify hemolysis as a critical driver of liver injury in ALD, linking red blood cell breakdown to inflammation, iron overload, and disease progression.   https://doi.org/10.1016/j.redox.2025.103742

• 2024 Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes 

                see video here                 https://youtu.be/koGPRRZQn3E?t=27 

ABOUT CAR

Our long term goals are 

• to better understand underlying molecular mechanisms of liver diseases

• to improve diagnosis and therapy of liver diseases 

Translational research topics focus on 

• liver diseases

• alcohol-related liver disease

• hepatology and liver diseases

• cancer (hepatocellular and colorectal cancer)

• non-invasive diagnosis of liver fibrosis, fatty liver and hepatic iron overload

• fatty liver and steatohepatitis

• non-invasive detection of liver iron

• iron overload disorders

• liver stiffness 

Basic research topics are related to

• hemolysis and red blood cell degradation

• eryptosis

• molecular mechanisms of oxidative stress 

• redox-regulation

• detection of reactive oxygen species

• novel models for oxidative stress and hypoxia

• inflammation and iron homeastasis 

• mechanisms of alcohol-mediated cancerogenesis

• biomechanics and extracellular matrix (fibrosis and cirrhosis)

Our work is presently funded by the DFG and NIH 

Former financial supporters include DFG, NIH ,Dietmar-Hopp Foundation and the Manfred-Lautenschläger Foundation.

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Archived former news:

• Prof. Mueller appointed 2023 as Visiting Professor of Guangxi Medical University, Nanning, PRC

• Prof. Mueller appointed 2022 as Visiting Professor of The Roger Williams Institute of Hepatology (affiliated to Kings's College London)

• ESBRA 2021 was successfully held in Timisoara, Romania from  October 7-10 2021 (European Society for Biomedical Research on Alcoholism Conference – 2021 (medevents.ro)

• EMG Webinar on "Liver elastography for early diagnosis of liver cirrhosis"  16.5.2022

• First comprehensive book on "Liver elastography: Clinical use and interpretation" by Sebastian Mueller and published by Springer Nature  2020

• New DFG grant to Sebastian Mueller 2020-2026 on "NAPDH oxidases and alcohol-related liver disease"

• Sebastian Mueller elected as the new ESBRA president 2017-2021

• Novel grant from the Dietmar-Hopp foundation granted to Sebastian Mueller on "Longterm survival and alcohol consumption" 2018-2021 

• DFG Grant to Vanessa Rausch und Sebastian Mueller, RA 2677/1-1 'Mechanisms of cancerogenic iron accumulation in alcoholic liver disease (ALD)'. 

• Novel funding on non-invasive assessment of liver iron by room-temperature susceptometry by the Dietmar-Hopp Foundation. 

• Member of the genome-wide case-control study on enetic risk factors for alcoholic cirrhosis" 

• Webinar in 11th MAy 2016 in Paris on alcoholic liver disease and non-invasive fibrosis screening (Youtube link 60 min)

• Novel DFG Grant to Sebastian Mueller, MU 1373/9-1 on a fundamentally novel concept of liver cirrhosis (Mechanisms of sinusoidal pressure-induced liver fibrosis). For information see also here and new hypothesis paper in WJG 2016.

Mueller Lopez Family