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Prof. Sebastian Mueller, M.D., Ph.D.

Professor of Medicine (Gastroenterology/Hepatology)

Academic affiliations

Former Director, Center for Alcohol Research, University of Heidelberg

Otto Meyerhof Zentrum, INF350, 69120 Heidelberg
Direct contact:

Visiting Professorships

The Roger Williams Institute of Hepatology (2022-2025) in London/UK (affiliated to King's College London)
Guangxi Medical University in Nanning/VR China (since 2023)
Past President, ESBRA

Publications

GOOGLE SCHOLAR

News

New book on "Alcohol and alcohol-related diseases", edited by Sebastian Mueller and Markus Heilig and published by Springer Nature. Addresses all aspects of alcohol-related diseases from addiction to alcohol-related liver disease, alcoholic hepatitis and cancer. With contributions from more than 100 authors from 17 countries. 2 volumes. 1600 pages.
Webinar on "Alcoholic hepatitis" for the International Grand Rounds Series 2 of the British Society of Gastroenterology (broadcast on June 27th 2024).

Recent publications

2026 Phosphatidylserine-Dependent Clearance of Damaged Red Blood Cells by Liver Sinusoidal Endothelial Cells in Alcohol-Related Liver Disease

Hemoglobin deposition in human liver tissue

Hemoglobin autofluorescence is a specific hallmark of alcohol-related liver disease, confirmed by its colocalization with hemoglobin immunostaining in human liver tissue. Note that autofluorescence of liver sections mirrors hemoglobin deposition.

2025 Redox Biology: Evidence for alcohol-mediated hemolysis and erythrophagocytosis

We identify hemolysis as a critical driver of liver injury in ALD, linking red blood cell breakdown to inflammation, iron overload, and disease progression. https://doi.org/10.1016/j.redox.2025.103742

2024 Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes

Hepatocytes directly ingest and degrade oxidized or ethanol-damaged red blood cells via efferocytosis, revealing a novel mechanism that may contribute to hepatic iron overload in alcohol-related liver disease.

Watch the hepatocyte efferocytosis video

About CAR

Our long term goals are

to better understand underlying molecular mechanisms of liver diseases
to improve diagnosis and therapy of liver diseases

Former financial supporters include DFG, NIH, Dietmar-Hopp Foundation and the Manfred-Lautenschläger Foundation.

DFG GEPRIS

Mueller Lopez Family