Sebastian Mueller, MD, PhD

 

Professor of Medicine,

 

CAR, University of Heidelberg 

 

 

 

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Sebastian Mueller

Prof. Sebastian Mueller, M.D., Ph.D.

Professor of Medicine (Gastroenterology/Hepatology)

Academic affiliations

Otto Meyerhof Zentrum, INF350, 69120 Heidelberg
Direct contact: Direct contact

Visiting Professorships

Publications

GOOGLE SCHOLAR

Books 

  • S. Mueller, M. Heilig, Alcohol and Alcohol-related Diseases, Springer Cham2023. [Publisher] [Amazon]
  • S. Mueller, Liver Elastography: Clinical Use and Interpretation, Springer International Publishing2020. [Publisher] [Amazon]

News

  • New book on "Alcohol and alcohol-related diseases", edited by Sebastian Mueller and Markus Heilig and published by Springer Nature. Addresses all aspects of alcohol-related diseases from addiction to alcohol-related liver disease, alcoholic hepatitis and cancer. With contributions from more than 100 authors from 17 countries. 2 volumes. 1600 pages.
  • Webinar on "Alcoholic hepatitis" for the International Grand Rounds Series 2 of the British Society of Gastroenterology (broadcast on June 27th 2024).

Recent publications

“The Red Blood Cell–Liver Axis: A New Framework for Iron Homeostasis and Liver Biology” has been published in Biology. The article presents the Red Blood Cell–Liver Axis as a conceptual framework linking erythrocyte turnover, iron homeostasis, redox biology and liver function.

The red blood cell–liver axis as the central regulator of systemic iron homeostasis
The Red Blood Cell–Liver Axis links erythrocyte turnover and erythrocyte-derived signals to hepatic hepcidin regulation and systemic iron homeostasis. For more details of the concept read article

Hemoglobin deposition in human liver tissue

Hemoglobin autofluorescence is a specific hallmark of alcohol-related liver disease, confirmed by its colocalization with hemoglobin immunostaining in human liver tissue. Note that autofluorescence of liver sections mirrors hemoglobin deposition.

Alcohol-mediated hemolysis and erythrophagocytosis

We identify hemolysis as a critical driver of liver injury in ALD, linking red blood cell breakdown to inflammation, iron overload, and disease progression. https://doi.org/10.1016/j.redox.2025.103742

Hepatocytes directly ingest and degrade oxidized or ethanol-damaged red blood cells via efferocytosis, revealing a novel mechanism that may contribute to hepatic iron overload in alcohol-related liver disease.

Hepatocyte efferocytosis video

Watch the hepatocyte efferocytosis video

 

About CAR

Our long term goals are

  • to better understand underlying molecular mechanisms of liver diseases
  • to improve diagnosis and therapy of liver diseases

Former financial supporters include DFG, NIH, Dietmar-Hopp Foundation and the Manfred-Lautenschläger Foundation.

DFG GEPRIS

 

 

 

Mueller Lopez Family

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